Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design
نویسندگان
چکیده
منابع مشابه
Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design.
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a potential drug target because of its role in the development of Down syndrome and Alzheimer's disease. The selective DYRK1A inhibitor 10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acid (KuFal194), a large, flat and lipophilic molecule, suffers from poor water solubility, limiting its use as chemical probe in cellular ...
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ژورنال
عنوان ژورنال: Molecules
سال: 2018
ISSN: 1420-3049
DOI: 10.3390/molecules23020064